Original article baicalin ameliorates isoproterenol induced acute myocardial infarction through inos, inflammation, oxidative stress and p38mapk pathway in rat shenjie sun, xiaopeng wu, hengliang song, guiqi li department of cardiology, the second hospital affiliated to zhengzhou university, zhengzhou 450014, henan, china. Introduction myocardial infarction mi is an important cause of mortality around the world, resulting. Effect of kefir against isoproterenol induced myocardial infarction in rats 269 gutteridge jm. Pdf evaluation of cardioprotective role of vinpocetine.
Pdf evaluation of cardioprotective role of vinpocetine in. Curcumin has antiinflammatory, antioxidative, anticarcinogenic, and cardiovascular protective effects. Sixty rats were randomly divided into six groups of 10 rats each. Luteolin7diglucuronide attenuates isoproterenolinduced. Myocardial infarction mi is an important cause of mortality around the world, resulting from an ischemic necrosis induced by a vascular occlusion. The effect of astragaloside iv on isoproterenolinduced myocardial infarction in rats article pdf available in pharmaceutical sciences 252. Sequential changes of energy metabolism and mitochondrial function in myocardial infarction induced by isoproterenol in rats. A tool for inducing myocardial infarction in experimental animals, authormohd aftab siddiqui and usama sharif ahmad and ahmed abdullah khan and mohammad ayaz ahmad and badruddeen and mohammad khalid and juber akhtar, year2016. Cardioprotective effect of melatonin against isoproterenol induced myocardial infarction in rats. Blood and tissue samples liver, brain, adrenal glands, normal and necrotic areas of the heart were collected 15, 30, and 45 minutes after tracer injection. Wistar male albino rats were randomly divided and treated with extract of cardamom 100 and 200 mgkg per oral or normal saline for 30 days with concomitant administration of iso 85 mgkg, subcutaneous on 29th and 30th days, at 24 h interval. Vasodilators may play positive role in myocardial infarction mi. Role of nitric oxide in isoproterenolinduced myocardial.
Henceforth, in the present study, myocardial ischemia mi was created in wistar rats using isoproterenol iso, a wellestablished model for investigating mi. Possible effect of natural honey on isoproterenol induced. Protective effects of cardamom in isoproterenolinduced. Mature male rats with isoproterenol induced myocardial infarction and normal controls were injected intravenously with 1, 23 h corticosterone 3 h corticosterone. Myocardial infarction induction with isoproterenol raised leukocytes and neutrophils counts, sgot, troponin i and urea concentrations, reduced catalase enzyme. The rat model of isoproterenol induced myocardial infarction offers. Guidelines of our institutional animal ethical committee iaec. Shift in antioxidant parameters, lactate dehydrogenase ldh together with morphological and histopathological changes were investigated. All national and international guidelines for the care and use of animals were closely followed. Europium hydroxide nanorods ehns ameliorate isoproterenol. The activities of creatine kinase on myocardial bundle ckmb and lactate dehydrogenase ldh were also reduced. Myocardial damage induced by a single high dose of. Mar 20, 2009 abstract the present study evaluated cardioprotective effect of lyophilized hydroalcoholic extract of moringa oleifera in the isoproterenol isp induced model of myocardial infarction.
Six weeks before the induction of myo cardial infarction, some of the animals had been orchiectomized or ovari ectomized. Pdf isoproterenolinduced myocardial infarction in wistar rats. Jan 04, 2007 we studied the cardioprotective effect of squalene on isoprenaline induced myocardial infarction in male albino rats with respect to changes in the levels of lipid components in plasma and heart ti. However, the cardioprotective effects of puerarinv on myocardial infarction mi heart failure are still unclear. Wogonin, one of the main active ingredients of scutellaria radix, is a kind of flavonoid compound. Cardioprotective effect of fenugreek on isoproterenolinduced myocardial infarction in rats. Ginsenoside re is the main chemical component of panax ginseng. Myocardial infarction induced by isoproterenol iso. Polyphenol was extracted from cocoa using a hydroalcohol solvent. The acute phase of myocardial necrosis induced by isoproterenol mimics changes in blood pressure, heart rate, electrocardiogram ecg, and left ventricular dysfunction similar to that occurring in patients with myocardial infarction. However, the effect of ritonavir on cardiac glut4 inhibition during myocardial necrosis is not investigated. The effect of pretreatment with curcumin nanoparticles nc compared to conventional curcumin cs on blood pressure, electrocardiogram, and biological changes on isoproterenol iso induced myocardial. The inflammatory responses play a major role in the pathogenesis of acute myocardial infarction mi. Apoptosis, inflammation, isoprenaline, myocardial infarction.
Protective effect of scutellarin on myocardial infarction induced by. In fact, mi, an acute condition of necrosis of myocardium is the most lethal. Moringa oleifera leaf extract prevents isoproterenolinduced. Artile investigation of the protective effect of kefir.
Possible effect of natural honey on isoproterenol induced acute myocardial infarction in adult male albino rats marwa a omar, fatma elnabawia, a elsafty, wael b elkholy and abeer e elmehi department anatomy and embryology, faculty of medicine, menoufia university, menoufia, egypt submission. Pdf the effect of astragaloside iv on isoproterenol. Forty albino rats divided into six groups of four rats each were used for the. In this research, we aim to evaluate the cardioprotective effects of puerarinv on the isoproterenol iso induced mi mice and elucidate the underlying mechanisms. Cardio protective role of wogonin loaded nanoparticle against. Experimental model of myocardial infarction induced by. Mechanism of isoproterenol induced myocardial damage. Protective effect of taurine on myocardial antioxidant status. Jan 23, 2017 the animal model of iso induced myocardial injury recapitulates major metabolic and morphological changes that occur during human myocardial infarction, thus being widely adopted as an.
Exercise training, indomethacin, and isoproterenolinduced. Effects of curcumin nanoparticles in isoproterenolinduced. Rats were randomly assigned to exercise and control groups. Original article baicalin ameliorates isoproterenolinduced. Myocardial infarction induced by isoproterenol iso using toxic concentration of this. Tacrolimus ameliorates functional disturbances and oxidative stress in isoproterenol induced myocardial infarction arash khorrami1,2, mojtaba hammami2, mehraveh garjani2, nasrin malekidizaji1 and alireza garjani1 abstract background. Jan 11, 2020 our study is aimed at evaluating the effects of pretreatment with polylactic. The rats were subcutaneously injected with isoproterenol iso 85 mgkg at an interval of 24 hours for two days. Fifty wistar strain male albino rats, weighing 200 10, were selected for the study. Nov 23, 2017 sequential changes of energy metabolism and mitochondrial function in myocardial infarction induced by isoproterenol in rats. We have examined the protective effect of taurine on the myocardial antioxidant defense system in isoprenaline isoproterenol induced myocardial infarction in rats, an animal model of myocardial infarction in man. Myocardial trauma and damage were induced by two doses of isoproterenol 40 mgkg. The present study is undertaken to evaluate the effect of esculetin on the levels of lipid peroxidation and antioxidants in isoproterenol iso induced myocardial infarction mi in wistar rats. Mature male rats with isoproterenolinduced myocardial infarction and normal controls were injected intravenously with 1, 23h corticosterone 3h corticosterone.
Curcumin nanoparticles protect against isoproterenol induced. This model becomes relevant if we consider that increased adrenergic. Therefore, mi in animal models studies should be induced in conscious animals with intact reflexes for greater clinical re levance. Male wistar rats were orally given ginsenoside re 5, 20 mgkg daily for 7 days. The protective impact of betaine on the tissue structure and. Preventive effect of esculetin on lipid peroxides and. This study aimed to investigate the protective effect of betaine on tissue structure and renal function after isoprenaline. For this,tamoxifen was administered to spraguedawley rats for 114 days, and isoproterenol iso 100 mgkg body mass. Clinical guidelines distinguish between myocardial injury and myocardial infarction mi. Ginsenoside re attenuates isoproterenolinduced myocardial. The animals were autopsied at regularly timed intervals on days 1, 2, 3, 8, and 15 after myocardial infarction. Diabetes and isoproterenol induced myocardial infarction was evident as a reduction in maximal positive and negative rate of developed left ventricular pressure and an increase in left ventricular enddiastolic pressure. Myocardial infarction is usually induced in small animals by means of invasive techniques based on mechanical coronary obstruction.
Dec 14, 2018 however, the cardioprotective effects of puerarinv on myocardial infarction mi heart failure are still unclear. Tacrolimus ameliorates functional disturbances and oxidative. While myocardial injury encompasses any type of acute myocardial damage such as necrosis induced by myocarditis, sepsis or endogenous catecholamines, mi is defined as ischemic damage resulting from an insufficient myocardial oxygen supply 1 2. Pretreatment with black cumin offered a protective effect against isoproterenol induced myocardial infarction in rats as evidenced by cardiac markers and lipid profile of the heart tissue. In the present study, we report that wogonin nanoparticles wog np protect isoproterenol iso induced myocardial infarction mi rats. As it has been reported that isoproterenol can cause ischemic myocardial alterations, lipid peroxide generation and procoagulant activity, we administered it to rabbits in order to induce a noninvasive myocardial infarction associated with above mentioned. Article pdf available in international research journal of. A biochemical, electrocardiographic and histoarchitectural evaluation. Cc on isoproterenol iso induced myocardial infarction mi in rats. Thirty young, male, wistar rats 145 to 230 g were randomly allocated in two groups. Pdf the effect of astragaloside iv on isoproterenolinduced. Vinpocetine is a phosphodiesterase type1 inhibitor having strong vasodilating effect through camp and cgmp elevation.
Isoproterenolinduced myocardial infarction in rabbits. Mi is the most clinically encountered ischemic heart diseases and remains. Alprazolam decreases isoproterenol induced myocardial damage. It was hypothesized that endurance exercise training would attenuate isoproterenolinduced myocardial necrosis in the rat by increasing the concentration of prostacyclin in the myocardial vasculature. Isoproterenolinduced myocardial infarction in rats. Cardioprotective potential of ocimum sanctum in isoproterenol. Origination and development of isoproterenolinduced myocardial infarction in male wistar rats. Cardioprotective effect of squalene on lipid profile in.
Lipid peroxidation and antioxidants as biomarkers of tissue damage. In addition to its antiviral effect, ritonavir directly inhibits the insulinregulated glucose transporter glut4 and blocks glucose entry into fat and muscle cells. Adult male and female spraguedawley rats were subjected to an isopro terenol induced myocardial infarction. Protective effects of cardamom in isoproterenolinduced myocardial. Curcumin from curcuma longa is a nutraceutical compound reported to possess strong antioxidant activity that makes it a candidate for use in counteracting oxidative stress induced damage. Myocardial infarction, lipid peroxidation, black cumin, cardiac markers myocardial infarction mi is a therapeutic. In the present study, we evaluated the role of ritonavir in isoproterenol induced. Two hundred mgkg iso dose was selected for the present study as this dose offered significant. Sham group, which underwent a virtual myocardial infarction induction, and. The protective effect of scu on isoinduced mi was evaluated by measuring markers of. Pdf the present study was designed to investigate the cardioprotective effects of sundarban honey sh in rats with isoproterenol iso induced. The present study was designed to investigate the cardioprotective effects of sundarban honey sh in rats with isoproterenol iso induced myocardial infarction.
Further, these proangiogenic nanorods were also reported to exhibit a mild to nontoxic nature toward mammalian cells and mouse models. Cardioprotective effects of puerarinv on isoproterenol. Acute treatment with metformin improves cardiac function. Based on the results presented, we conclude that the model of myocardial infarction induced by isoproterenol in rats was adequately reproduced and validated in our laboratory and caused increased mortality and myocardial injury markers ast and troponin i, reduction of catalase activity and levels of glutathione and histopathological changes. Isoproterenol iso administration induced the myocardial injury as evidenced by. Cardioprotective effect of ritonavir, an antiviral drug, in.
Isoproterenol injections alone caused the expected cardiotoxicity. Effect of gonadectomy on isoproterenolinduced myocardial. Curcumin and curcumin nanoparticles were given by gavage in three di. Beneficial role of tamoxifen in isoproterenolinduced.
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